Ismat Ara Begum1, Farhana Islam1, Md. Wahiduzzaman Akanda2, Jolly Biswas3,Sufia Begum4, Md. Rashidul Hassan5, Md. Naimul Hoque6
Abstract:
Background: Hepatitis B virus ( HBV) and MDR TB represents major public
health problems. There is currently little data on HBV infection among MDRTB
patients with or without Human immunodeficiency virus (HIV) and
Hepatitis C virus (HCV).
Objectives: 1. To assess HBV, HCV and HIV prevalence among MDR TB
patients. 2. To reduce MDR-TB/HIV, MDR-TB/HBV N MDR-TB/HCV
associated morbidity and mortality.
Study Design:From January 2012 to June 2013 a cross sectional study was
conducted among MDR patients admitted in NIDCH Mohakhali, Dhaka,
Bangladesh. The participants were tested for serological markers of HBV
surface antigen, HIV and HCV antibodies. HBV positive samples were detected
by ELISA method.
Results:106 patients of MDR – TB were agreed to participate in the study.MDR
– TB patients were between 14-70 years and Male 59(55.64%)and Female
47(44.34%) . Among 106 patients only 3(2.83%) were HBsAg positive and 103
patients (97.17%) were HBsAg negative but all patients were HIV and HCV
negative. A higher rate of HBV infection was found among MDR – TB patients
3 (2.83%). A multivariate analysis of risk factors shows that age group 21 to
30 years is more affected.47(44.34%) in MDR-TB. HBsAg positive total 3
samples were tested by ELISA method.
Conclusion: HBV infection is common among MDR-TB patients. In this
study there was no patient with MDR-TB/HIV and MDR-TB/HCV. But to
reduce the risk of morbidity and mortality of patients detected with HBV and
TB/HIV special attention is to be addressed.
Key words: MDR-TB , HBV screening , HIV.