Md. Shahedur Rahman Khan1, Jalal Mohsin Uddin2, Bashir Ahmed1,Md Khairul Hassan Jessy1, Biswas Akhtar Hossain1, Biswas Shaheen Hassan3,
Md Ziaul Karim4, Md.Abu Raihan1, Barkat Ullah3, K.C. Ganguly1, Md. Abdur Rouf1,Selina Akter5, Jibesh Kumar Pramanik2,

Abstract:
The insidious onset and non-specific constitutional symptoms of genitourinary
tuberculosis (GUTB) often lead to delayed diagnosis and rapid progression to a
non-functioning kidney. Genitourinary tuberculosis (GUTB),is a worldwide
disease, but shows a more destructive behavior in developing countries like
Bangladesh. GUTB usually affects adults between the second and fourth decades
of life. There is often a long latent period (5-40 years) between the original
pulmonary infection and the appearance of clinical renal disease,9 Most patients
present with local symptoms such as frequent voiding; dysuria, pyuria, back or
flank or abdominal pain 1-5 and microscopic or macroscopic hematuria12
Conventionally, demonstration of mycobacterium in urine has been used as the
primary test for the diagnosis of GUTB. Preferably, five consecutive early-morning
specimens of urine should be examined.21 Urine analysis of sediment from a 24-
hour specimen for acid-fast bacilli (AFB) is positive in 80-90% of cases of TB. Gene
X-pert test The technique of PCR is rapid, with results available within few hours
of DNA extraction from the sample. It is highly specific (up to 88%) and its sensitivity
in detecting urine acid-fast bacilli (AFB) has been reported in up to 94% of the
cases.22,23A negative chest radiograph and tuberculin test cannot exclude the
diagnosis of extra-pulmonary TB.9 The intravenous urogram (IVU) remains the
gold standard in imaging early renal TB. Ultrasonography is a poor modality to
show morphological changes. The overall incidence of renal failure reported in the
literature is 24%.10 There are three mechanisms by which TB can cause renal failure.
Keywords: Genitourinary Genitourinary TB, EPTB, Genital TB, Urinary TB

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