Nirmal Kanti Sarkar1, Hosne Sadat2, Md. Abu Raihan3, Md. Khairul Anam4, Moumita Roy5, S.M. Abdur Razzaque6, BipulKanti Biswas7, Nihar Ranjan Saha7, Abdullah Al Muzahid1, Bijoy Krashna Das8
Abstract:
Paradoxical response is referred to an unusual expansion or formation of a new lesion during successful anti-tuberculous chemotherapy (ATT).In general tuberculosis is the most common cause of pleural effusion but development of pleural effusion during successful anti-tuberculous chemotherapy is uncommon.In our case, a young man was diagnosed as sputum smear negative pulmonary
tuberculosis and ATT was started. He responded to treatment but 12 days later he developed right sided pleural effusion. A paradoxical pleural effusion was suspected. We continued ATT with addition of oral corticosteroid and the patient was under observation. Pleural effusion subsided over time and the patient was
recovered completely without any further complication. Development of pleural effusion in patient getting ATT may be due to a paradoxical response having an immunological basis, and does not necessarily require nay modification in chemotherapy. Strong suspicion is needed to diagnose such case.
Key words: Anti-tuberculous chemotherapy (ATT), Paradoxical effusion.